ACTIONS:
The antiparasitic action of Safe-Guard® (fenbendazole)
Paste 10% is believed to be due to the inhibition of energy
metabolism in the parasite.
Safe-Guard® (fenbendazole) Paste
10% is indicated for the control of large strongyles (Strongylus
edentatus, S. equinus, S. vulgaris), encysted early
third stage (hypobiotic), late third stage and fourth stage
cyathostome larvae, small strongyles, pinworms (Oxyuris
equi), ascarids (Parascaris equorum), and
arteritis caused by fourth stage larvae of Strongylus
vulgaris in horses.
Safe-Guard®(fenbendezole) Paste 10% is approved
for use concomitantly with an approved form of trichlorfon.
Trichlorfon is approved for the treatment of stomach bots (Gasterophilus
spp.) in horses. Refer to the manufacturer''''s label
for directions for use and cautions for trichlorfon.
CONTRAINDICATIONS:
There are no known contraindications for the use of
Safe-Guard® (fenbendazole) Paste 10% in horses.
Safe-Guard® (fenbendazole) Paste
10% is administered orally at a rate of 2.3 mg/lb (5mg/kg)
for the control of large strongyles, small strongyles, and
pinworms. For control of encysted early third stage (hypobiotic),
late third stage and fourth stage cyathostome larvae,and
fourth stage larvae of Strongylus vulgaris, the
recommended dose is 4.6 mg/lb (10 mg/kg) daily for 5
consecutive days.
DIRECTIONS FOR USE:
1. Determine the weight of the horse.
2. Remove syringe tip.
3. Turn the dial ring until the edge of the ring nearest the
tip lines up with zero.
4. Depress plunger to advance paste to tip.
5. Now set the dial ring at the graduation nearest the
weight of the horse (do not underdose).
6. Horse''s mouth must be free of food.
7. Insert nozzle of syringe through the interdental space
and deposit the paste on the back of the tongue by
depressing the plunger.
Side effects associated with Safe-Guard®
(fenbendazole) Paste 10% could not be established in
well-controlled safety studies in horses with single doses
as high as 454 mg/lb (1,000 mg/kg) and 15 consecutive daily
doses of 22.7 mg/lb (50 mg/kg). Particularly with higher
doses, the lethal action of fenbendazole may cause the
release of antigens by the dying parasites. This phenomenon
may result in either a local or systemic hypersensitive
reaction. As with any drug, these reactions should be
treated symptomatically.
Safe-Guard® (fenbendazole) Paste 10% has been
evaluated for safety in pregnant mares during all stages of
gestations with doses as high as 11.4 mg/lb (25 mg/kg) and
in stallions with doses as high as 11.4 mg/lb (25 mg/kg). No
adverse effects on reproductivity were detected. The
recommended dose for control of 4th stage larvae of Strongylus
vulgaris, 4.6 mg/lb (10mg/kg) daily for 5 consecutive
days, has not been evaluated for safety in stallions or
pregnant mares.
CAUTIONS: Keep this and all medication out of the reach
of children.
WARNING: Do not use in horses intended for food.